|
KMID : 0387420120230020121
|
|
Korean Society of Oriental Neuropsychiatry
2012 Volume.23 No. 2 p.121 ~ p.128
|
|
|
Single Oral Dose Toxicity Test of ACM(Added Chongmyung-tang) in Sprague-Dawley Rat
|
|
Choi Woo-Chang
Jung In-Chul
Lim Jong-Soon
Lee Sang-Ryong
Kim Seung-Hyung
|
|
|
Abstract
|
|
|
Objectives: This research investigates the single oral dose toxicity of ACM in SD rats.
Methods: ACMs were administered to female and male SD rats, as an oral dose of 5000 mg/kg. Animals were monitored for the mortality and changes in the body weight, clinical signs and gross observation during the 14 days after dosing, upon necropsy.
Results: We could not find any mortality. Compared with the control group, significant weight change was not observed in the experimental group. First day after administration, compound-colored stool was observed in all rats. After the second day of administration, the more common symptoms were not observed. There were no gross abnormalities in all cases. [ED NOTE: highlight: given the context, this is very vague]
Conclusions: The results obtained in this study suggest that the approximate lethal dose of ACM in both female and male rats were considered as over 5000 mg/kg.
|
|
|
KEYWORD
|
|
|
ACM, Added Chongmyung-Tang, single oral dose toxicity, SD rats
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|